GCN2 activator-1
GCN2 activator-1 (Compound 20) is a GCN2 activator that binds to the ATP pocket of GCN2 and activates it in a GCN1-independent manner. It can stimulate the integrated stress response (ISR) in cells and inhibits PKR with an IC50 of 3.75 μM. GCN2 activator-1 is utilized for research on pulmonary veno-occlusive disease (PVOD) .
Product Specifications
CAS Number
315705-10-3
Field of Research
Cell Biology, Signal Transduction
Smiles
N=1C=CC=NC1NC2=NC (=CS2) C=3SC (=NC3C) N
Molecular Formula
C11H10N6S2
Molecular Weight
290.37
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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