(-) -JJ-450
(-) -JJ-450 is a non-competitive antagonist targeting the androgen receptor (AR) . It is more effective than (+) -JJ-450 in inhibiting androgen-induced AR activity, while (+) -JJ-450 inhibits AR via a mechanism distinct from Enzalutamide (MDV3100), possibly targeting the ligand-binding domain (LBD) of AR. (-) -JJ-450 inhibits transcriptional activity of both wild-type AR and the mutant ARF876L by suppressing AR nuclear translocation and promoting intranuclear degradation of unbound AR. This compound can be utilized in research focusing on castration-resistant prostate cancer (CRPC) that is resistant to Enzalutamide.
Product Specifications
CAS Number
1998094-23-7
Field of Research
Metabolism Research
Smiles
C (=O) ([C@@H]1[C@@H] (C1) C2=CC=C (F) C=C2) N3CCN (CC3) C4=C (C) C=CC (Cl) =C4
Molecular Formula
C21H22ClFN2O
Molecular Weight
372.86
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Recombinant Acanthamoeba polyphaga mimivirus Uncharacterized protein R351 (MIMI_R351)
Recombinant Acanthamoeba polyphaga mimivirus Uncharacterized protein R351 (MIMI_R351)
Recombinant Acanthamoeba polyphaga mimivirus Uncharacterized protein R351 (MIMI_R351)
Recombinant Acanthamoeba polyphaga mimivirus Uncharacterized protein R351 (MIMI_R351)
Recombinant Acanthamoeba polyphaga mimivirus Uncharacterized protein R351 (MIMI_R351)