SJ11646
SJ11646 is a Dasatinib-based LCK PROTAC degrader with a DC50 of 0.00838 pM. It exhibits potent cytotoxicity against LCK-activated T-cell acute lymphoblastic leukemia (T-ALL) cells and primary leukemia samples, significantly prolongs LCK signal inhibition, and induces apoptosis in T-ALL cells. SJ11646 binds with high affinity to 51 human kinases, particularly ABL1, KIT, and DDR1. In mouse models of T-ALL, SJ11646 demonstrates exceptional anti-leukemic efficacy.
Product Specifications
CAS Number
2933135-82-9
Field of Research
Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Smiles
O=C (NC=1C (Cl) =CC=CC1C) C=2SC (=NC2) NC=3N=C (N=C (C3) N4CCN (CC4) CCCNC (=O) COC5=CC=C (C=C5) C6C (=O) NC (=O) CC6) C
Molecular Formula
C36H40ClN9O5S
Molecular Weight
746.28
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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