(S) -Ceralasertib
(S) -Ceralasertib ((S) -AZD6738) is the S-enantiomer of Ceralasertib. (S) -Ceralasertib is the inhibitor for ataxia telangiectasia mutated and rad3 related (ATR).
Product Specifications
CAS Number
1352226-87-9
Product Name Alternative
(S) -AZD6738
UNSPSC
12352005
Target
ATM/ATR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/s-ceralasertib.html
Purity
99.97
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=[S@](C1(CC1)C2=NC(C3=C4C(NC=C4)=NC=C3)=NC(N5CCOC[C@H]5C)=C2)(C)=N
Molecular Formula
C20H24N6O2S
Molecular Weight
412.51
References & Citations
[1]By Foote, et al. Morpholinopyrimidines as ATR kinase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of cancer. PCT Int. Appl. (2011), WO 2011154737 A1 20111215.|[2]Foote KM, et al. Discovery and Characterization of AZD6738, a Potent Inhibitor of Ataxia Telangiectasia Mutatedand Rad3 Related (ATR) Kinase with Application as an Anticancer Agent. J Med Chem. 2018 Nov 21;61 (22) :9889-9907.|[3]Espinar L, et al., Nuclear IMPDH2 controls the DNA damage response by modulating PARP1 activity. Nat Commun. 2024 Nov 12;15 (1) :9515.|[4]Olmedo-Pelayo J, et al. EWS:: FLI1-DHX9 interaction promotes Ewing sarcoma sensitivity to DNA topoisomerase 1 poisons by altering R-loop metabolism[J]. BioRxiv, 2023: 2023.05. 30.542894.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
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