(S) -Ceralasertib

(S) -Ceralasertib ((S) -AZD6738) is the S-enantiomer of Ceralasertib (HY-19323) . (S) -Ceralasertib is the inhibitor for ataxia telangiectasia mutated and rad3 related (ATR) [1].

Product Specifications

CAS Number

[1352226-87-9]

Product Name Alternative

(S) -AZD6738

UNSPSC

12352005

Target

ATM/ATR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; PI3K/Akt/mTOR

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/s-ceralasertib.html

Purity

99.97

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=[S@](C1(CC1)C2=NC(C3=C4C(NC=C4)=NC=C3)=NC(N5CCOC[C@H]5C)=C2)(C)=N

Molecular Formula

C20H24N6O2S

Molecular Weight

412.51

References & Citations

[1]By Foote, et al. Morpholinopyrimidines as ATR kinase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of cancer. PCT Int. Appl. (2011), WO 2011154737 A1 20111215.|[2]Foote KM, et al. Discovery and Characterization of AZD6738, a Potent Inhibitor of Ataxia Telangiectasia Mutatedand Rad3 Related (ATR) Kinase with Application as an Anticancer Agent. J Med Chem. 2018 Nov 21;61 (22) :9889-9907.|[3]Espinar L, et al., Nuclear IMPDH2 controls the DNA damage response by modulating PARP1 activity. Nat Commun. 2024 Nov 12;15 (1) :9515.|[4]Olmedo-Pelayo J, et al. EWS:: FLI1-DHX9 interaction promotes Ewing sarcoma sensitivity to DNA topoisomerase 1 poisons by altering R-loop metabolism[J]. BioRxiv, 2023: 2023.05. 30.542894.