ISM7594
ISM7594 is an orally active FGFR2/3 inhibitor demonstrating broad-spectrum antiproliferative capabilities in cancer cell lines with FGFR2 or FGFR3 alterations, such as amplification, fusion, and mutation (e.g., BaF3-TEL-FGFR2-V564F with an IC50 of 0.067 nM, BaF3-TEL-FGFR2-V564I with an IC50 of 2 nM) . It inhibits tumor growth in a dose-dependent manner and is suitable for research on advanced solid tumors with FGFR2/3 abnormalities.
Product Specifications
CAS Number
3025799-76-9
Field of Research
Cardiovascular Research, Signal Transduction
Smiles
O=C (N) C1=C2C=C (C=NN2C (C=3C=CC (=CC3) NC (=O) C (F) =C) =C1C4=CC=C (OC5=NC=CC (=N5) C) C (F) =C4) C
Molecular Formula
C29H22F2N6O3
Molecular Weight
540.52
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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