ASIC1a antagonist-1
ASIC1a antagonist-1 (Compound 5b) is an orthosteric non-competitive antagonist of the acid-sensing ion channel 1a (ASIC1a) with an IC50 of 27 nM at pH 6.7. It alters the pH dependency of ASIC1a activation and suppresses its maximum response. Additionally, ASIC1a antagonist-1 completely inhibits the induction of long-term potentiation (LTP) in the CA3-CA1 pathway. This compound is useful for research into brain diseases and pathologies.
Product Specifications
CAS Number
1787243-08-6
Field of Research
Neuroscience; Pharmacology & Drug Discovery, Pharmacology & Drug Discovery
Smiles
O=C1OC2=C (C=C1C (N) =N) C=CC (N (CCN (CC) CC) CC3=CC=C (C=C3) Cl) =C2.Cl.Cl
Molecular Formula
C23H29Cl3N4O2
Molecular Weight
499.86
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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