Dextran sulfate sodium salt (MW 16000-24000)

Dextran sulfate sodium salt (DSS) (MW 16000-24000) is a polymer of dehydrated glucose with a molecular weight of approximately 16000-24000. Dextran sulfate sodium salt with different molecular weights exhibits different biological activities. Dextran sulfate sodium salt (MW 16000-24000) induces STING polymerization and TBK1 activation[1].

Product Specifications

CAS Number

[9011-18-1]

Product Name Alternative

DSS (MW 16000-24000) ; DXS (MW 16000-24000)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Biochemical Assay Reagents; STING

Type

Reference compound

Related Pathways

Immunology/Inflammation; Others

Applications

Neuroscience-Neurodegeneration

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/dextran-sulfate-sodium-salt-mw-20000.html

Solubility

DMSO : < 1 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 100 mg/mL (ultrasonic)

Smiles

[Dextransulfatesodiumsalt(MW16000-24000)]

Molecular Weight

16000-24000

Precautions

H302, H315, H319, H335

References & Citations

[1]Fang R, Jiang Q, Guan Y, Gao P, Zhang R, Zhao Z, Jiang Z. Golgi apparatus-synthesized sulfated glycosaminoglycans mediate polymerization and activation of the cGAMP sensor STING. Immunity. 2021 May 11;54 (5) :962-975.e8.|[2]Laumonier T, et al. Low molecular weight dextran sulfate binds to human myoblasts and improves their survival after transplantation in mice. Cell Transplant. 2013;22 (7) :1213-26.