PfPK6-IN-1

PfPK6-IN-1 is a potent and selective inhibitor of PfPK6 with an IC50 value of 0.3 μM. It inhibits the formation of malarial pigment, affecting the unique heme detoxification pathway specific to the parasite, with an IC50 of 13 μM for β-hematin (βH) . PfPK6-IN-1 demonstrates rapid and broad-spectrum antimalarial properties, effective against both sensitive and drug-resistant strains of the parasite. This compound can be utilized in research on antimalarial agents.