P-gp-IN-30
P-gp-IN-30 (Compound 13) is an inhibitor of P-glycoprotein (P-gp) that targets YB-1. It reduces the expression of total YB-1 protein and nuclear YB-1 protein, thereby inhibiting the expression and function of downstream P-gp, which significantly enhances sensitivity to paclitaxel by inhibiting its efflux rate. When combined with paclitaxel, P-gp-IN-30 effectively suppresses tumor growth in A549/Taxol xenograft mouse models. This compound is useful for research on non-small cell lung cancer (NSCLC) .
Product Specifications
CAS Number
2761881-65-4
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Smiles
C (OCC) (=O) C1 (C (OCC) =O) [C@@]2 ([C@@H] ([C@H] (N1) C=3[C@@]4 ([C@] (CC3) (C (C (OC) =O) =CO[C@H]4OC) [H]) [H]) C5=CC=CC=C5) C=6C (NC2=O) =CC=CC6
Molecular Formula
C34H36N2O9
Molecular Weight
616.66
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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