NCI677397
NCI677397 is a USP24 inhibitor. It enhances lipid ROS, activates cholesterol and fatty acid biosynthesis, and degrades ABC transporters, GPX4, and DHFR through the autophagy pathway. This process reduces p-gp levels, ultimately leading to ferroptosis in drug-resistant cancer cells. NCI677397 is relevant for research in lung and brain cancers.
Product Specifications
CAS Number
907547-06-2
Field of Research
Cell Biology, Immunology & Inflammation, Metabolism Research, Molecular Biology, Protein Biochemistry
Smiles
O=C (C=1C=CC=CC1) C2=CC=C3SC=4C=CC=CC4N (C3=C2) CCCCN5CCN (C) CC5
Molecular Formula
C28H31N3OS
Molecular Weight
457.63
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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