NTRC 0066-0
NTRC 0066-0 is a selective threonine tyrosine kinase (TTK) inhibitor (IC50=0.9 nM) . NTRC 0066-0 can be used for the research of cancer[1].
Product Specifications
CAS Number
[1817791-73-3]
UNSPSC
12352005
Target
Mps1
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ntrc-0066-0.html
Concentration
10mM
Purity
99.01
Solubility
DMSO : 20.83 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=C2CCC3=CN=C(NC4=CC=C(N5CCN(C)CC5)C=C4OC)N=C3N2C=C1)NC6=C(CC)C=CC=C6CC
Molecular Formula
C33H39N7O2
Molecular Weight
565.71
References & Citations
[1]Uitdehaag JCM, et al. Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity. J Mol Biol. 2017;429 (14) :2211-2230.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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