NTRC 0066-0

NTRC 0066-0 is a selective threonine tyrosine kinase (TTK) inhibitor (IC50=0.9 nM) . NTRC 0066-0 can be used for the research of cancer[1].

Product Specifications

CAS Number

[1817791-73-3]

UNSPSC

12352005

Target

Mps1

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ntrc-0066-0.html

Concentration

10mM

Purity

99.01

Solubility

DMSO : 20.83 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=C2CCC3=CN=C(NC4=CC=C(N5CCN(C)CC5)C=C4OC)N=C3N2C=C1)NC6=C(CC)C=CC=C6CC

Molecular Formula

C33H39N7O2

Molecular Weight

565.71

References & Citations

[1]Uitdehaag JCM, et al. Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity. J Mol Biol. 2017;429 (14) :2211-2230.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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