PBD dimer-4

PBD dimer-4 (Compound 7) is a C1-substituted PBD dimer. This compound exhibits high DNA-binding affinity, effective DNA cross-linking ability, and potent cytotoxicity against MDA-MB-231 cells (IC50: 236 nM) . PBD dimer-4 serves as a payload in the ADC drug Loncastuximab tesirine, utilized for treating various cancer types.