KBD4466
KBD4466 is a potent oral inhibitor of TLR7 and TLR8, with IC50 values of 0.9 nM and 2.8 nM, respectively. This compound effectively suppresses the inflammatory cytokines IL-6 and IFN-α. KBD4466 has shown to improve disease progression and increase survival rates in the BXSB/MpJ mouse model of systemic lupus erythematosus (SLE) . It is suitable for research into autoimmune diseases.
Product Specifications
CAS Number
3023713-87-0
Field of Research
Immunology & Inflammation
Smiles
C (F) (F) (F) [C@@]12[C@@] (C1) (CN (C2) C=3C4=C (C (C#N) =CC3) N=CC=C4) C=5OC (=NN5) C6CCN (C) CC6
Molecular Formula
C24H23F3N6O
Molecular Weight
468.47
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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