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PROTAC EGFR degrader 13

PROTACEGFRdegrader 13 (compound 106) is an EGFR PROTAC degrader with a DC50 of less than 0.1 μM. It demonstrates antiproliferative activity against Ba/F3-TEL-EGFR-T790M-L858R-C797S cells, with an IC50 of 15.6 nM. PROTACEGFRdegrader 13 is applicable in the research of EGFR-related diseases, such as cancer.

Product Specifications

CAS Number

2861227-35-0

Field of Research

Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Smiles

O=C1C2=CC=C (C=C2C (=O) N1C3C (=O) NC (=O) CC3) N4CCN (CC4) CC5CCN (C=6C=C (OC) C (=CC6C=7C=NN (C7) C) NC8=NC=C (Br) C (=N8) NC9=CC=C (C=C9P (=O) (C) C) C%10CC%10) CC5

Molecular Formula

C49H55BrN11O6P

Molecular Weight

1004.91

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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