10-Butyl Ether Minocycline
10-Butyl EtherMinocycline is a derivative of Minocycline and acts as an inhibitor of MMP-8 and MMP-9, with IC50 values of 69.4 μM and 47.0 μM, respectively. It exhibits negligible antibacterial activity against E. coli, S. typhi, and C. albicans. Additionally, 10-Butyl EtherMinocycline inhibits LPS-induced microglial activation and VEGF-induced endothelial cell migration, as well as L-Glutamine-induced ROS levels. This compound significantly reduces alcohol consumption in a chronic intermittent ethanol (CIE) mouse model and is utilized in studies related to neuroinflammation and alcohol use disorder (AUD) .
Product Specifications
CAS Number
488815-65-2
Field of Research
Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery, Protein Biochemistry
Smiles
O[C@]12[C@] ([C@H] (N (C) C) C (O) =C (C (N) =O) C1=O) (C[C@]3 (C (=C2O) C (=O) C=4C (C3) =C (N (C) C) C=CC4OCCCC) [H]) [H]
Molecular Formula
C27H35N3O7
Molecular Weight
513.58
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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