STING-IN-16

STING-IN-16 is an inhibitor of STING, with an IC50 value of 44 nM in humans and 32 nM in mice. This compound effectively suppresses the activation of the STING pathway in both human and mouse cells. STING-IN-16 aids in restoring kidney mitochondrial function, inhibits the production of reactive oxygen species (ROS), and reduces apoptosis. It exhibits significant anti-inflammatory effects in vivo and is a valuable tool for researching autoimmune and autoinflammatory diseases.