Mesutoclax
Mesutoclax (ICP-248) (Compound 5) is a selective BCL-2 inhibitor with an IC50 of 1.54 nM, demonstrating weak activity against BCL-XL (IC50: >1000 nM) . It inhibits the viability of RS4;11 cells with an IC50 of 2.75 nM and can be utilized in cancer research.
Product Specifications
CAS Number
2760536-87-4
Field of Research
Cell Biology
Purity
98.96% (May vary between batches)
Smiles
C (C1=C (CC (C) (C) CC1) C2=CC=C (Cl) C=C2) N3[C@H] (C) CN (CC3) C4=CC (OC=5C=C6C (=NC5) NC=C6) =C (C (NS (=O) (=O) C7=CC (N (=O) =O) =C (NC[C@H]8COCCO8) C=C7) =O) C=C4
Molecular Formula
C45H50ClN7O8S
Molecular Weight
884.44
Storage Conditions
-20°C
Notes
For research use only.
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