AR antagonist 12
AR antagonist 12 (compound 20i) is an orally active androgen receptor antagonist, demonstrating IC50 values of 119.3 μM for wt-AR and 98.2 μM for AR-F877L. It induces a dose- and time-dependent reduction in the protein levels of AR, AR-v7, and PSA. AR antagonist 12 exhibits anticancer activity, making it useful in the study of Enzalutamide-resistant prostate cancer.
Product Specifications
CAS Number
2902679-42-7
Field of Research
Metabolism Research, Pharmacology & Drug Discovery
Smiles
C ([C@] (C (NC=1C=C (C (F) (F) F) C (C#N) =NC1) =O) (C) O) N2CC3N (C (C2) CC3) C4=CC=C (C#N) C=C4
Molecular Formula
C24H23F3N6O2
Molecular Weight
484.47
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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