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P2Y14R antagonist 5

P2Y14R antagonist 5 (Compound A) is a novel P2Y14R antagonist with a benzisoxazole-based structure, exhibiting an IC50 of 23.60 nM and a KD of 7.26 μM. This compound can reduce levels of pro-inflammatory factors (IL-1β, IL-6, TNF-α) and myeloperoxidase (MPO) . It demonstrates anti-inflammatory activity in a mouse model of LPS-induced acute lung injury.

Product Specifications

Field of Research

Neuroscience, Pharmacology & Drug Discovery

Storage Conditions

-20°C

Notes

For research use only.

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