KRASG12D-IN-5
KRASG12D-IN-5 (Compound 241) is an orally active KRAS (G12D) inhibitor with an IC50 of 11 nM. It demonstrates potent anticancer activity without significant cytotoxicity to BxPC-3 cells (wild-type), KRAS-mutant AsPC-1 cells (G12D), and MIAPaCa-2 cells (G12C), with CC50 values of 10.37, 0.76, and 0.3 μM, respectively. KRASG12D-IN-5 is applicable in cancer studies, including lung, pancreatic, and colorectal cancers.
Product Specifications
CAS Number
2933935-13-6
Field of Research
Signal Transduction
Smiles
C (OC=1N=C (C2=C (N1) C (F) =C (N=C2) C=3C4=C (C=C (O) C3) C=CC (F) =C4C#C) N5CC6 (C (F) F) NC (C5) CC6) [C@@]78N (C[C@H] (F) C7) CCC8
Molecular Formula
C34H31F5N6O2
Molecular Weight
650.64
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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