HSD17B13-IN-104

HSD17B13-IN-104 (Compound 32) is an orally active and potent inhibitor of HSD17B13 with high selectivity (IC50=2.5 nM) . It modulates liver lipid metabolism by inhibiting the SREBP-1c/FAS pathway and blocks the enzymatic activity of HSD17B13 to alleviate hepatic lipid accumulation. HSD17B13-IN-104 shows potential for research in metabolic dysfunction-associated fatty liver disease.