Z218484536
Z218484536 is a selective phosphoserine phosphatase (PSPH) inhibitor that can penetrate the blood-brain barrier. It binds to PSPH with an affinity (Kd) of approximately 0.23 μM. By doing so, Z218484536 reduces levels of L-serine and D-serine in astrocytes. It also inhibits spontaneous seizures without causing significant side effects and demonstrates effective antiepileptic properties in the temporal lobe epilepsy (TLE) model.
Product Specifications
CAS Number
1223877-07-3
Field of Research
Metabolism Research
Smiles
O=C (N) NN=CC1=CNN=C1C=2C=CC (F) =CC2
Molecular Formula
C11H10FN5O
Molecular Weight
247.23
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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