INCB126503
INCB126503 is an orally active and selective inhibitor of FGFR2/3, with IC50 values of 70 nM for FGFR1, 2.1 nM for FGFR2, 1.2 nM for FGFR3, 0.92 nM for FGFR3-V555L, 0.85 nM for FGFR3-V555M, and 64 nM for FGFR4. This compound inhibits FGFR signaling in vivo without causing hyperphosphatemia and demonstrates antitumor efficacy in xenograft models with FGFR3 genetic alterations.
Product Specifications
CAS Number
2640089-88-7
Field of Research
Cardiovascular Research, Signal Transduction
Smiles
O (C) C=1C=C2C (C (=NN2) C=3C=CC (=NC3) N4C[C@]5 (N (CC4) C[C@H] (O) C5) [H]) =NC1C6=C (C) C (C) =CC=C6
Molecular Formula
C27H30N6O2
Molecular Weight
470.57
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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