FC-14369
FC-14369 is a PROTAC degrader targeting the HIV-1Nef protein (HIV-1Nef protein) with a DC50 value of 160 nM. By means of its bifunctional structure, FC-14369 binds to both Nef and Cereblon E3 ubiquitin ligase, facilitating Nef ubiquitination and proteasomal degradation. This action restores the expression of cell surface CD4 and MHC-I, thereby inhibiting HIV-1 replication. FC-14369 is applicable in the study of HIV infection and AIDS.
Product Specifications
CAS Number
3066894-28-5
Field of Research
Infectious Disease & Virology, Pharmacology & Drug Discovery, Protein Biochemistry
Smiles
O=C1NC (=O) C (N2C (=O) C=3C=CC=C (NCCNC (=O) COC4=CC=C (C=C4) CCC=5C (=NN (C6=NC=7C=C (Cl) C=CC7N6) C5O) C=8C=CC (=CC8) C (F) (F) F) C3C2=O) CC1
Molecular Formula
C42H34ClF3N8O7
Molecular Weight
855.22
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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