PROTAC EGFR degrader 12
PROTACEGFRdegrader 12 (example 1) is a PROTAC degrader that selectively targets and degrades mutant EGFR, with minimal effect on EGFRWT. It demonstrates an IC50 of less than 50 nM against EGFRL858R-T790M (NCI-H1975 cells), EGFRL858R (NCI-H3255 cells), and EGFRL858R-T790M-L797S (NCI-H1975+CS cells) .
Product Specifications
CAS Number
2654821-05-1
Field of Research
Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Smiles
C (CC1 (O) CCN (CC1) C2=C (F) C=C (N[C@@H]3C (=O) NC (=O) CC3) C=C2) (=O) N4CC5 (CN (C5) C6=CC=C (C=C6) C=7C=C8C (=C (F) C7) CN (C (C (NC9=NC=CS9) =O) C%10=C%11N (C=N%10) CCC%11) C8=O) C4
Molecular Formula
C48H48F2N10O6S
Molecular Weight
931.02
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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