TAU-IN-3

TAU-IN-3 (Compound 2) is an orally active TAU inhibitor that suppresses the expression of the MAPT exon 10 DDPAC mutant gene in HeLa cells (IC50: 0.6 μM) . It reduces the 4R/3R MAPT mRNA ratio in HeLa cells transfected with WT or DDPAC minigenes. TAU-IN-3 inhibits the insertion of endogenous MAPT exon 10 and the production of 4R tau protein. It modulates tau splicing in htau mice and improves associated behavioral phenotypes. TAU-IN-3 is useful for researching neurodegenerative diseases.