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WZH-17-002

WZH-17-002 is an ALKPROTAC degrader based on WZH-15-125, with a DC50 of 25 nM. This compound enhances the efficacy against ALK mutations that confer resistance to Lorlatinib. Moreover, WZH-17-002 significantly reduces resistance in ALK fusion non-small cell lung cancer (NSCLC) and inhibits tumor growth in EML4-ALK G1202R/L1196M xenograft mouse models.

Product Specifications

Field of Research

Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction

Storage Conditions

-20°C

Notes

For research use only.

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