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RJG-2036

RJG-2036 is a potent covalent inhibitor of human prostaglandin reductase 2 (PTGR2) with an IC50 of 100 nM. It effectively inhibits NADPH-dependent reduction reactions, significantly reducing the secretion of inflammatory factors such as TNF-α and the release of various pro-inflammatory eicosanoids in LPS-stimulated THP-1 macrophages. RJG-2036 shows promise for research in inflammatory diseases.

Product Specifications

CAS Number

2851993-73-0

Field of Research

Immunology & Inflammation, Pharmacology & Drug Discovery

Smiles

O=C (C1=CC=CC (=C1) S (=O) (=O) N2N=CN=C2) N3CCN (C=4C=CC=CC4OC) CC3

Molecular Formula

C20H21N5O4S

Molecular Weight

427.48

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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