AH001
AH001 is an orally active compound that binds to a concealed pocket near GDP within RhoA, exhibiting a binding affinity of 73.16 nM. By interacting with GDP, AH001 stabilizes the interaction between RhoA and its endogenous inhibitor, RhoGDIα. This compound reduces nuclear translocation of downstream MRTFA and downregulates fibrosis/hypertrophy-related proteins. AH001 alleviates myocardial remodeling in various heart failure animal models and 3D cardiac tissue models. Its cardioprotective effects are mediated through the RhoA-RhoGDIα axis, effectively inhibiting downstream RhoA activation signals.
Product Specifications
CAS Number
1456769-95-1
Field of Research
Signal Transduction
Smiles
[C@@H] (CO) (O) C1=CC (CC) =CC=C1
Molecular Formula
C10H14O2
Molecular Weight
166.22
Storage Conditions
-20°C
Notes
For research use only.
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