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WZH-15-125

WZH-15-125 is a potent ALK inhibitor capable of overcoming resistance, particularly with complex ALK mutations. It exhibits an IC50 of 101.7 nM against the highly recalcitrant Lorlatinib-resistant G1202R/L1196M mutation. Additionally, WZH-15-125 can serve as a PROTAC target protein ligand for synthesizing PROTACWZH-17-002. This compound is applicable in non-small cell lung cancer research.

Product Specifications

CAS Number

2845188-22-7

Field of Research

Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction

Smiles

O=S (=O) (N (C1=C2OCCOC2=CC=C1NC3=NC (=NC=C3Br) NC=4C=C (C (=CC4OC) N5CCC (N6CCN (C) CC6) CC5) CC) C) C

Molecular Formula

C33H45BrN8O5S

Molecular Weight

745.73

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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