WZH-15-125
WZH-15-125 is a potent ALK inhibitor capable of overcoming resistance, particularly with complex ALK mutations. It exhibits an IC50 of 101.7 nM against the highly recalcitrant Lorlatinib-resistant G1202R/L1196M mutation. Additionally, WZH-15-125 can serve as a PROTAC target protein ligand for synthesizing PROTACWZH-17-002. This compound is applicable in non-small cell lung cancer research.
Product Specifications
CAS Number
2845188-22-7
Field of Research
Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction
Smiles
O=S (=O) (N (C1=C2OCCOC2=CC=C1NC3=NC (=NC=C3Br) NC=4C=C (C (=CC4OC) N5CCC (N6CCN (C) CC6) CC5) CC) C) C
Molecular Formula
C33H45BrN8O5S
Molecular Weight
745.73
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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