PROTAC PI3K/110β degrader-2
PROTACPI3K/110β degrader-2 is a selective PI3K/p110β PROTAC degrader. It effectively degrades the 110β protein and inhibits the expression of P-glycoprotein. Additionally, it increases reactive oxygen species (ROS) levels. PROTACPI3K/110β degrader-2 exerts antitumor effects by activating the endoplasmic reticulum stress (ERS) mediated mitochondrial apoptosis pathway and inhibiting the AKT/Bcl-2 signaling pathway. This compound is applicable in cancer research.
Product Specifications
CAS Number
3070438-79-5
Field of Research
Cell Biology, Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction
Smiles
C (NC1=C (C (NCCCCCCC (N[C@H] (C (=O) N2[C@H] (C (NCC3=CC=C (C=C3) C=4SC=NC4C) =O) C[C@@H] (O) C2) C (C) (C) C) =O) =O) C=CC=C1) (C) C=5C=6N (C (=O) C=C (N6) N7CCOCC7) C=C (C) C5
Molecular Formula
C51H65N9O7S
Molecular Weight
948.18
Storage Conditions
-20°C
Notes
For research use only.
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