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Antitrypanosomal agent 26

Antitrypanosomal agent 26 (Compound 1) is an allosteric inhibitor of trypanosome alternative oxidase (TAO) . It exhibits potent activity against African trypanosomes, such as Trypanosoma brucei, with an IC50 value of 1.3 nM for recombinant TAO. The compound disrupts the mitochondrial electron transport chain of trypanosomes and inhibits glucose-dependent respiration. Antitrypanosomal agent 26 shows potential for research in treating African animal trypanosomiasis, including bovine trypanosomiasis.

Product Specifications

CAS Number

2601665-22-7

Field of Research

Infectious Disease & Virology

Smiles

[Br-].O=C (OCCCCCCCCCCCCCC[P+] (C1=NC=CC=C1) (C=2C=CC=CC2) C=3C=CC=CC3) C4=CC=C (O) C=C4C

Molecular Formula

C39H49BrNO3P

Molecular Weight

690.69

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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