Antitrypanosomal agent 26
Antitrypanosomal agent 26 (Compound 1) is an allosteric inhibitor of trypanosome alternative oxidase (TAO) . It exhibits potent activity against African trypanosomes, such as Trypanosoma brucei, with an IC50 value of 1.3 nM for recombinant TAO. The compound disrupts the mitochondrial electron transport chain of trypanosomes and inhibits glucose-dependent respiration. Antitrypanosomal agent 26 shows potential for research in treating African animal trypanosomiasis, including bovine trypanosomiasis.
Product Specifications
CAS Number
2601665-22-7
Field of Research
Infectious Disease & Virology
Smiles
[Br-].O=C (OCCCCCCCCCCCCCC[P+] (C1=NC=CC=C1) (C=2C=CC=CC2) C=3C=CC=CC3) C4=CC=C (O) C=C4C
Molecular Formula
C39H49BrNO3P
Molecular Weight
690.69
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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