Modzatinib
Modzatinib (ITKkinase-IN-1) (compound I) is an inhibitor targeting ITK kinase with an IC50 of 8 nM in Jurkat cells, useful for researching inflammatory diseases. In hPBMC cells, it inhibits JAK3 with an IC50 of 23 nM (based on IL-2/pSTAT5 levels) and shows no inhibitory effect on JAK2.
Product Specifications
CAS Number
2411407-25-3
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Purity
99.15% (May vary between batches)
Smiles
N (C1=C2C (=CNC2=NC=N1) [C@@H]3C (F) (F) C3) [C@H]4CN (C (C=C) =O) [C@@H] (C) CC4
Molecular Formula
C18H21F2N5O
Molecular Weight
361.39
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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