PAN endonuclease-IN-3

PAN endonuclease-IN-3 is a potent inhibitor of PAN endonuclease, with an IC50 of 17.4 nM against the influenza virus polymerase complex. It demonstrates strong antiviral activity against various strains of current influenza viruses while exhibiting very low cytotoxicity in MDCK cells. In mice models infected with A/WSN/33, PAN endonuclease-IN-3 significantly suppresses viral replication.