PFE-360

PFE-360 (PF-06685360) is a potent, selective, brain penetrated and orally active leucine-rich repeat kinase 2 (LRRK2) inhibitor with a mean IC50 of 2.3 nM in vivo[1][2].

Product Specifications

CAS Number

[1527475-61-1]

Product Name Alternative

PF-06685360

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

LRRK2

Type

Reference compound

Related Pathways

Autophagy

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pfe-360.html

Purity

99.48

Solubility

DMSO : 10.42 mg/mL (ultrasonic)

Smiles

N#CC1=CC(C2=CNC3=NC=NC(N4CCOCC4)=C32)=CN1C

Molecular Formula

C16H16N6O

Molecular Weight

308.34

Precautions

H315, H319, H320

References & Citations

[1]Marco A.S. Baptista, et al. LRRK2 Kinase Inhibitors of Different Structural Classes Induce Abnormal Accumulation of Lamellar Bodies in Type II Pneumocytes in Non-Human Primates but are Reversible and Without Pulmonary Functional Consequences.|[2]Andersen MA, et al. Parkinson's disease-like burst firing activity in subthalamic nucleus induced by AAV-α-synuclein is normalized by LRRK2 modulation. Neurobiol Dis. 2018 Aug;116:13-27.|[3]Andersen MA, et al. PFE-360-induced LRRK2 inhibition induces reversible, non-adverse renal changes in rats. Toxicology. 2018 Feb 15;395:15-22.