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NLRP3-IN-81

NLRP3-IN-81 (N102) is an inhibitor capable of crossing the blood-brain barrier, effectively countering NLRP3 inflammasome-dependent pyroptosis with an EC50 of 0.029 μM for Nigericin-induced pyroptosis. It significantly suppresses caspase-1 activation and IL-1β release that depend on NLRP3. Additionally, NLRP3-IN-81 disrupts the interaction between NLRP3 and the adaptor protein ASC, while inhibiting ASC oligomerization. This compound is applicable in research on pyroptosis-related diseases, such as inflammatory bowel disease and type 2 diabetes.

Product Specifications

CAS Number

2922814-85-3

Field of Research

Cell Biology, Immunology & Inflammation, Protein Biochemistry

Smiles

O=S (=O) (C1=NN=C (C=C1) C=2C=CC (=CC2O) C (F) (F) F) C3CCCC3

Molecular Formula

C16H15F3N2O3S

Molecular Weight

372.36

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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