Hsp90-Cdc37-IN-4
Hsp90-Cdc37-IN-4 is a novel derivative of triptolide that inhibits the protein-protein interaction (PPI) between Hsp90 and Cdc37. It selectively inhibits casein kinase 2 (CK 2), reducing the phosphorylation of its substrate Cdc37 at the serine 13 site. Additionally, Hsp90-Cdc37-IN-4 induces cell cycle arrest in the G0/G1 phase and triggers apoptosis via the mitochondrial pathway. This compound exhibits significant anti-breast cancer activity.
Product Specifications
CAS Number
2758818-41-4
Field of Research
Cell Biology, Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology
Smiles
C[C@@]12[C@] (C) ([C@]3 ([C@@] (C) (CC1) CC[C@] (C (NCCCOC (/C=C/C4=CC=CC=N4) =O) =O) (C) C3) [H]) CC[C@]5 (C) C2=CC=C6C5=CC (=O) C (O) =C6C
Molecular Formula
C40H50N2O5
Molecular Weight
638.84
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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