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FC-14367

FC-14367 is a PROTAC degrader targeting the HIV-1Nef protein. It forms a ternary complex by binding Nef with CereblonE3 ubiquitin ligase, inducing ubiquitination of Nef and its subsequent proteasomal degradation. This restores cell surface CD4 and MHC-I expression, inhibiting HIV-1 replication. FC-14367 is useful for research on HIV infection and AIDS.

Product Specifications

CAS Number

3066893-65-7

Field of Research

Infectious Disease & Virology, Pharmacology & Drug Discovery, Protein Biochemistry

Smiles

O=C1NC (=O) C (N2C (=O) C=3C=CC=C (OCC (=O) N4CCC (C5=NN (C (O) =C5CCC6=CC=C (F) C=C6) C7=NC=8C=C (Cl) C=CC8N7) CC4) C3C2) CC1

Molecular Formula

C38H35ClFN7O6

Molecular Weight

740.18

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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