FC-14367
FC-14367 is a PROTAC degrader targeting the HIV-1Nef protein. It forms a ternary complex by binding Nef with CereblonE3 ubiquitin ligase, inducing ubiquitination of Nef and its subsequent proteasomal degradation. This restores cell surface CD4 and MHC-I expression, inhibiting HIV-1 replication. FC-14367 is useful for research on HIV infection and AIDS.
Product Specifications
CAS Number
3066893-65-7
Field of Research
Infectious Disease & Virology, Pharmacology & Drug Discovery, Protein Biochemistry
Smiles
O=C1NC (=O) C (N2C (=O) C=3C=CC=C (OCC (=O) N4CCC (C5=NN (C (O) =C5CCC6=CC=C (F) C=C6) C7=NC=8C=C (Cl) C=CC8N7) CC4) C3C2) CC1
Molecular Formula
C38H35ClFN7O6
Molecular Weight
740.18
Storage Conditions
-20°C
Notes
For research use only.
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