PROTAC ERα Degrader-11

PROTACERα Degrader-11 is a selective ERα PROTAC degrader with intrinsic fluorescence (Ex: 366 nm, Em: 440 nm) . It demonstrates strong anti-proliferative activity, selective ERα degradation, and fluorescence imaging capability in the MCF-7 breast cancer cell line. PROTACERα Degrader-11 induces G2/M phase arrest and apoptosis in MCF-7 cells. In athymic nude mice, it shows good safety with no acute toxic reactions at a dose of 500 mg/kg. PROTACERα Degrader-11 is suitable for breast cancer research.