Harpagide

Harpagide is a class of iridoid glycoside isolated from Scrophularia ningpoensis and has antiparasitic activity, which exhibits good in vitro trypanocidal activities against African trypanosomes (T.b. rhodesiense) with an IC50 of 21 μg/mL. Harpagide exerts significant antileishmanial activity against L. donovani with an IC50 value of 2.0 μg/mL. Harpagide also possess significant anti-inflammatory activities[1][2].

Product Specifications

CAS Number

[6926-08-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Parasite

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/harpagide.html

Purity

99.97

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@H]1[C@H](O)[C@@H](O)[C@]([H])(O[C@@H]2OC=C[C@]3(O)[C@@]2([H])[C@](O)(C)C[C@H]3O)O[C@@H]1CO

Molecular Formula

C15H24O10

Molecular Weight

364.35

Precautions

H302, H315, H319, H335

References & Citations

[1]Tasdemir D, et al. Evaluation of antiprotozoal and antimycobacterial activities of the resin glycosides and the other metabolites of Scrophularia cryptophila. Phytomedicine. 2008 Mar;15 (3) :209-15.|[2]Zhang L, et al. Effects of β-glucosidase hydrolyzed products of harpagide and harpagoside on cyclooxygenase-2 (COX-2) in vitro. Bioorg Med Chem. 2011 Aug 15;19 (16) :4882-6.|[3] Háznagy-Radnai E, et al. Cytotoxic activities of Stachys species. Fitoterapia. 2008 Dec;79 (7-8) :595-7.