7,4'-Dimethoxy-3-hydroxyflavone
7,4'-Dimethoxy-3-hydroxyflavone is an orally active PAR4 antagonist. This compound inhibits PAR4-mediated human platelet aggregation with an IC50 of 1.4 μM. It disrupts PAR4-mediated aggregation and related signaling pathways, including NF-κB, Ca2+/protein kinase C (PKC), Akt, ERK, and p38. In a streptozotocin (STZ) -induced diabetic mouse model, 7,4'-Dimethoxy-3-hydroxyflavone inhibits vascular PAR4 expression, improves endothelial dysfunction, and reduces oxidative stress. Additionally, it prevents thrombosis in mice without affecting bleeding time.
Product Specifications
CAS Number
13198-99-7
Field of Research
Epigenetics & Chromatin, Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction
Smiles
O=C1C (O) =C (OC2=CC (OC) =CC=C21) C=3C=CC (OC) =CC3
Molecular Formula
C17H14O5
Molecular Weight
298.29
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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