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LL-K-12-18

LL-K12-18 is a two-site molecular glue that enhances interaction between CDK12 and DDB1, stabilizing the complex and promoting selective degradation of cyclin K with an EC50 of 0.37 nM. It exhibits potent transcriptional repression and antiproliferative effects in tumor models, making it a valuable chemical tool for investigating transcriptional regulation and targeted protein degradation in cancer research.

Product Specifications

Field of Research

Cell Biology, Pharmacology & Drug Discovery

Purity

99.77% (May vary between batches)

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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