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LRK-4189

LRK-4189 is an orally active, selective PIP4K2C PROTAC degrader with a DC50 <500 nM in MOLT-4 cells. It induces endogenous apoptosis and activates the interferon signaling pathway, exhibiting antitumor activity against microsatellite stable (MSS) colorectal cancer (CRC) cells.

Product Specifications

CAS Number

3063346-83-5

Field of Research

Pharmacology & Drug Discovery

Purity

99.88% (May vary between batches)

Smiles

FC=1C (C2=CC (=CC=C2) N3C (=O) C=CC=C3) =NC (N[C@@H]4CC[C@@H] (NC (=O) [C@@H]5CC[C@H] (CC5) N6CCN (CC6) C7=C (F) C=C (N[C@@H]8C (=O) NC (=O) CC8) C=C7) CC4) =NC1

Molecular Formula

C43H49F2N9O4

Molecular Weight

793.9

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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