PRMT5-MTA-IN-1
PRMT5-MTA-IN-1 (Compound A9a) is an inhibitor of the protein arginine methyltransferase PRMT5-MTA. It suppresses the proliferation of colorectal cancer cells HCT116, both wild-type and MTAP del mutants, with IC50 values of 16 nM and 2.47 μM, respectively. Additionally, PRMT5-MTA-IN-1 demonstrates favorable hepatic microsomal stability, membrane permeability, and pharmacokinetic properties in CD-1 mice.
Product Specifications
CAS Number
3048425-88-0
Field of Research
Epigenetics & Chromatin
Smiles
CC=1C2=C (N=C (N) C1CO) C=C (F) C (C (N (C) [C@H]3C=4C (OC3) =CC (C (F) (F) F) =CC4) =O) =C2
Molecular Formula
C22H19F4N3O3
Molecular Weight
449.40
Storage Conditions
-20°C
Notes
For research use only.
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