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HuR degrader 2

HuRdegrader 2 (Compound 3) is a molecular glue that targets and degrades the RNA-binding protein Hu antigen R (HuR), achieving 30% degradation at 0.1 μM. It inhibits the proliferation of Colo-205 cancer cells with an IC50 of ≤200 nM. HuRdegrader 2 also shows high affinity for cereblon with an HTRF ratio < 0.02.

Product Specifications

CAS Number

3040301-46-7

Field of Research

Epigenetics & Chromatin, Pharmacology & Drug Discovery, Signal Transduction

Smiles

O=C1NC (=O) C (C2=COC=3C=C (C=CC32) C=4C=CN=C5NC=CC54) CC1

Molecular Formula

C20H15N3O3

Molecular Weight

345.35

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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